Diversity Oriented Synthesis of

Small Molecule Libraries

 Abstract

Successful completion of the human genome project necessitated the need to find small molecule inhibitors for many proteins at an enhanced rate.  The success of any high-throughput screening in search of biological activity depends on the number and diversity of the chemical library that is undergoing the screen.  Advances in combinatorial technologies enabled synthesis of large collections of compounds in short intervals of time. 

 Recently, in an effort to increase the success rate in identifying small molecule inhibitors, a new algorithm known as Diversity Oriented Synthesis (DOS) was formulated which effectively populates the three dimensional chemical space with diverse molecules.  This article introduces DOS and highlights its utility in combinatorial chemistry and organic synthesis.

 About the Author

Srinivas Hotha (Ph.D) is a scientist with National Chemical Laboratory, Pune, in the CombiChem-Bioresource Center, Division of Organic Chemistry: Synthesis. His research area includes diversity oriented synthesis of small molecules with carbohydrate scaffolds. He has received Young Scientist award by Indian National Science Academy (INSA) and has numerous publications in various scientific journals of international repute.

CRAMS - The Way Forward

 Abstract

The article deals with opportunities in outsourcing including custom synthesis and manufacturing, challenges faced, future focus areas to achieve leadership position and key aspects  of contractual agreements. The author hopes to provide the contractors as well as service providers information about factors and strategies that can help them succeed in this business.

 About the Authors

A Kanakagiri, General Manager (Technical Services) at Shasun Chemicals and Drugs Limited, is a chemical engineer with many years of experience in projects, process engineering and production in chemical & pharmaceutical industries.

 Dr Ashis Kumar Mukherjee is Chief Scientific Officer at Shasun. Educated in the USA he has been working as Research Scientist & Business Head in various pharmaceutical and contract research organizations.

Pulse Combustion Dryers

 Abstract

 Pulse combustion drying is an emerging technology. It involves ignition and extinguishing of a mixture of fuel and air in short bursts accompanied by high intensity sound waves, in contrast to the continuous combustion in conventional drying. Pilot test runs and technical reports show that these dryers have short drying time and faster rate of drying. This drying technique can be extended to a wide range of applications from inorganic materials, food and agriculture products to heat sensitive biomaterials, highly sticky pastes, etc. The article discusses some salient features of this emerging technology, recent developments and equipment design.

 About the Authors

 Dr Arun Mujumdar is Professor in the Dept of Mechanical Engineering, National University of Singapore. He is an international authority on Drying and has written several books and conducted seminars in many countries on the subject.

 WU Zhonghua (BEngg-food science; MEngg-Mech) is currently working for doctoral program on “Pulse combustion and its applications to drying” under Prof. Arun S. Mujumdar. His research interests are in the areas of novel drying technologies, food and agricultural products processing, pulse combustion, and mass and heat transfer processes.

 Gas Chromatography Mass Spectroscopy

– New Revolution In Analysis

 Abstract

Gas Chromatography-Mass Spectroscopy   (GC-MS) makes an effective combination for chemical analysis. It is a hyphenated analytical method, combining the seperating powers of GC and detection properties of MS.

 GC-MS is used to identify unknown componetns in a given sample by matching the resultant spectra with existing libraries. The sensitivity and specificity of the technique allows even minor components of a sample to be quantified to ppt level. The author describes this revolutionary technique and its advatnages over other analytical techniques and how to use it effectively for analysis and quantification of unknown components.

 About the Author

Abhijit Bhar is National Product Manager at Niulab Equipment Co Pvt Ltd, representing the chromatography product range of Thermo Electron. Earlier, he was associated with Netel Chromatograph and represented Varian Inc, as Territory Manager for Maharashtra and Gujarat.

Technologies For Recycling Of

Waste Water

Abstract

Water scarcity is a global problem that needs no introduction. Indiscriminate industrial development and exploitation of limited water sources are compelling every industry to seriously address the problem. Industries are considering many options to reduce their water usage and to recycle water to the extent possible, including selection of manufacturing technologies which minimise water use and produce less waste water. This article discusses recycling and explores various recycle technologies available for production of good quality water for various applications.

About the Author

YVV Satyanarayana, environmental engineer with a Masters Degree in Environmental Engineering, is Head-Technology of Ion Exchange (India) Limited (IEIL).

He has worked on design, engineering and execution of many medium and large-scale water and wastewater treatment projects. He has conducted and facilitated numerous technical training workshops and seminars for Ion Exchange India and its customers.

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